Renal Complications Post-mRNA Injection
'Spikeopathy' associated kidney disease from COVID-19 vaccination
A July 2023 article titled “Renal Complications Following COVID-19 Vaccination: A Narrative Literature Review” by V. Vudathaneni, et al. outlines various pathogenic mechanisms affecting renal structure and function. A few of the renal complications discussed in this article, include:
Immunologlobulin A (IgA) nephropathy
Minimal change disease
Glomerulonephritis
Acute kidney injury
Nephrotic syndrome
Anti-neutrophil cytoplasmic antibody-associated vasculitis
A temporal relationship has been established with many of these complications even though absolute causality remains unclear. For example, the authors state a “dysregulated T-cell response, transient systemic pro-inflammatory cytokine response, molecular mimicry, delayed hypersensitivity reaction to the vaccine, and other mechanisms such as hyperresponsive IgA, dysregulation of neutrophil extracellular traps were hypothesized as the possible mechanisms of linking renal complications and COVID-19 vaccination.”
The actual list of reported renal complications post-COVID-19 injection is extensive and involves multiple areas of direct renal injury such as acute kidney damage to coagulopathy (e.g., thrombotic microangiopathy) and vasculitis which can adversely affect the kidneys and other organs.
The emphasis of this short Substack article will be on three specific mechanisms that can explain renal complications post-mRNA injections likely occurring from ‘spikeopathy.’ These three mechanism include: molecular mimicry, dysregulated T-cell response, and delayed hypersensitivity reaction to the vaccine.
Dysregulated T-cell Response
Aberrant activation of the immune system in susceptible individuals can lead to a dysregulated T-cell response. T-cells, an important component of adaptive immunity, play significant roles in immune activation, memory, regulation, and via B-cell induction the production of antibodies. The T-cell dysregulation post-mRNA injection was found to cause alterations in glomerular permeability. The glomerulus is the main filtering unit of the kidney.
Delayed Hypersensitivity
Activation of B-cells occurs post-mRNA injection with the spike protein and other vaccine components (e.g., polyethylene glycol) acting as antigens. With a second dose re-exposure to these components a delayed hypersensitivity response is elicited. The aberrant activation triggers the release of pro-inflammatory cytokines which can cause renal injury.
Molecular Mimicry
Immune system activation to non-self spike protein (i.e., from SARS-CoV-2 or mRNA injection) produces antibodies which can cross-react with self-antigens such as transglutaminase. These cross-reacting antibodies are involved in autoimmune reactivity which leads to tissue injury. For example, transglutaminase 2 is a protein found in the extracellular matrix within the kidneys. It is a common target for the immune leading to kidney injury and fibrosis.
Conclusion
Every tissue in the human body appears to be a target of the spike protein whether its origin is from a SARS-CoV-2 infection or the mRNA injection. The concern with ‘spikeopathy’ post-mRNA injection is the intensity of the production of ‘spike’ (which is a much larger amount compared to virus exposure), the duration of production, and its whole body distribution. The kidneys have been an overlooked organ system in the broader discussion of mRNA injection injuries compared to other more well-known areas such as the brain and cardiovascular systems. However, with the article mentioned in this Substack post (along with its literature references) we all need to be on the look out for renal complications from post-mRNA injection.